Journal of Diabetology

CASE REPORT
Year
: 2018  |  Volume : 9  |  Issue : 2  |  Page : 65--67

Successful transition to sulphonylurea therapy from insulin in a child with permanent neonatal diabetes due to a KCNJ11 gene mutation


Venkatesan Radha1, Bhuvanagiri Ramya2, Sundaramoorthy Gopi1, Babu Kavitha1, Somayajula Preetika2, Kalpana Thai2, Ranjit Unnikrishnan3, Viswanathan Mohan3, Prasanna Kumar Gupta2 
1 Madras Diabetes Research Foundation, WHO Collaborating Centre for Non-communicable Diseases Prevention and Control, ICMR Centre for Advanced Research on Diabetes, Chennai, Tamil Nadu, India
2 Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre of Excellence in Diabetes Care, Chennai, Tamil Nadu, India
3 Madras Diabetes Research Foundation, WHO Collaborating Centre for Non-communicable Diseases Prevention and Control, ICMR Centre for Advanced Research on Diabetes; Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre of Excellence in Diabetes Care, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Venkatesan Radha
Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention and Control and IDF Centre of Excellence in Diabetes Care, No. 4, Conran Smith Road, Gopalapuram, Chennai - 600 086, Tamil Nadu
India

Neonatal diabetes mellitus (NDM) is a monogenic form of diabetes mellitus that occurs in the first 6 months of life. It is a rare condition with a prevalence of 1 in 100,000–500,000 live births. We report a 3-month-old girl child with high blood glucose levels. She was diagnosed with diabetes mellitus during the 28th day of life and was on treatment with insulin. She was admitted for the control of high blood glucose levels during which she was started on multiple daily insulin treatment, but the control had been poor. As the age of onset is <6 months of life, genetic analysis has been done. It revealed the presence of a heterozygous mutation p. Gly334Val (p. G334V) in KCNJ11 gene which confirmed the diagnosis of NDM. The child was successfully shifted from insulin to sulfonylureas, and the blood glucose levels are well maintained.


How to cite this article:
Radha V, Ramya B, Gopi S, Kavitha B, Preetika S, Thai K, Unnikrishnan R, Mohan V, Gupta PK. Successful transition to sulphonylurea therapy from insulin in a child with permanent neonatal diabetes due to a KCNJ11 gene mutation.J Diabetol 2018;9:65-67


How to cite this URL:
Radha V, Ramya B, Gopi S, Kavitha B, Preetika S, Thai K, Unnikrishnan R, Mohan V, Gupta PK. Successful transition to sulphonylurea therapy from insulin in a child with permanent neonatal diabetes due to a KCNJ11 gene mutation. J Diabetol [serial online] 2018 [cited 2022 Nov 30 ];9:65-67
Available from: https://www.journalofdiabetology.org/article.asp?issn=2078-7685;year=2018;volume=9;issue=2;spage=65;epage=67;aulast=Radha;type=0