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REVIEW ARTICLE
Year : 2022  |  Volume : 13  |  Issue : 4  |  Page : 331-339

Association of circulatory adiponectin with the parameters of Madras Diabetes Research Foundation-Indian Diabetes Risk Score


1 Department of Biochemistry, Integral Institute of Medical Sciences and Research (IIMS&R), Integral University, Lucknow, India; Department of Biochemistry, United Institute of Medical Sciences, Rawatpur, Prayagraj, India
2 Department of Biochemistry, King George’s Medical University (KGMU), Lucknow, India
3 Department of Biochemistry, Integral Institute of Medical Sciences and Research (IIMS&R), Integral University, Lucknow, India
4 Department of Biochemistry, United Institute of Medical Sciences, Rawatpur, Prayagraj, India
5 Department of Biochemistry, Integral Institute of Medical Sciences and Research (IIMS&R), Integral University, Lucknow, India; Department of Basic Medical Sciences, Integral Institute of Allied Health Sciences and Research (IIAHSR), Integral University, Lucknow, Uttar Pradesh, India

Correspondence Address:
Dr. Mohammad M Khan
Department of Basic Medical Sciences, Integral Institute of Allied Health Sciences and Research (IIAHSR), Integral University, Lucknow, Uttar Pradesh 226026
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jod.jod_86_22

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Introduction: Adiponectin (APN) is an adipose-derived protein. It has shown a variety of functions such as anti-inflammatory, anti-atherogenic, antidiabetic, and insulin-sensitizing and lipid-oxidation-enhancing activities. The APN levels have shown a significant relationship with the risk factors for type 2 diabetes mellitus (T2DM). As per the Madras Diabetes Research Foundation-Indian Diabetes Risk Score (MDRF-IDRS), Asian Indians have high risk factors for T2DM and its complications. APN levels influence the risk factors for T2DM and its complications. Its circulatory level also varied with the age, family history of T2DM, waist circumference, and level of physical activity. Aim: The purpose of this narrative review is to find the association of circulatory APN with the parameters of MDRS-IDRS. Materials and Methods: Articles were searched by various databases such as PubMed, MEDLINE, Scopus, Web of Science, and Google Scholar. Abstract, free full-text, and full-text articles were searched from the year 2003 to 2022. For this review, observational study, original articles, narrative review, systematic review, and meta-analysis articles published in the English language were included. It is needed to establish the association between the APN levels and the parameters of MDRF-IDRS. The modifiable risk factors of MDRF-IDRS may play a significant role to regulate the level of APN. The non-modifiable risk factors of MDRF-IDRS may help in the better management of APN levels and reduce the prevalence of T2DM. It is needed to clear that the APN levels influence the disease severities or not. It is also needed to improve the physical activity to regulate the APN level and to reduce the systemic inflammation and insulin resistance in Asian Indian population. Conclusion: Improvement in modifiable risk factors of MDRF-IDRS and level of APN may play a significant role in the therapeutic approach to prevent and/or delay the development of T2DM and its complications.


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