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ORIGINAL ARTICLE
Year : 2021  |  Volume : 12  |  Issue : 4  |  Page : 434-441

Clusters and components of metabolic syndrome (MeS) as a predictor for fatty liver: A cross-sectional study


1 Department of Hepatology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India
2 Department of Gastroenterology, Arihant Hospital and Research Centre, Indore, Madhya Pradesh, India
3 Department of General Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Varanasi Yugandar Bhargav
Department of Hepatology, Sri Ramachandra Institute of Higher Education and Research, Chennai 600116, Tamil Nadu.
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jod.jod_17_21

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Aim: Metabolic syndrome (MeS) refers to metabolic risk factors with different phenotype combinations. The study aim was to determine the clusters of MeS components by age and gender as predictors for the presence of fatty liver (FL). Materials and Methods: The cohort consisted of 990 subjects, undergoing executive health check between January 2019 and February 2020. Baseline data, anthropometric parameters, and ultrasound findings were noted. Patients with normal ultrasound were categorized as group 1 and those with FL as group 2. MeS is defined and clustered and risk of predicting FL was analyzed in age and gender. Results: Of the 990 subjects, 689 (69.6%) had FL (group 2); 554 patients (56%) were >45 years. Females had significant grade 1 (P < 0.05) and grade 2 (P < 0.01) FL, ≥45 years, and MeS of three or more components in FL, both above (P < 0.01) and below (P < 0.03) 45 years of age. Waist circumference (WC), diabetes mellitus (DM) with hypertension, triglyceride, and high-density lipoprotein (cluster 3) were statistically significant in males, both <45 and >45 years of age (P < 0.001); in females, the same cluster was statistically significant only for >45 years (P <0.001). Conclusion: Females ≥45 years had significant FL. MeS of three or more components was seen in both above and below 45 years in females with FL when compared with males. The highest risk clusters were the ones that included WC and WC + DM, indicating that the clusters associated with WC alone or in combination with DM had the highest risk for FL when compared with the other MeS combinations.


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