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Year : 2016  |  Volume : 7  |  Issue : 1  |  Page : 2

Circulating omentin-1 levels and its association with insulin resistance in newly diagnosed impaired glucose tolerant subjects

1 Department of Biochemistry & Molecular Biology, Jahangirnagar University, Savar, Bangladesh
2 Department of Biochemist ry & Cell Biology, Bangladesh University of Health Sciences, Dhaka, Bangladesh
3 Department of Biochemistry & Molecular Biology, Rajshahi University, Rajshahi, Bangladesh

Correspondence Address:
L Ali
Department of Biochemistry & Cell Biology, Bangladesh University of Health Sciences, Dhaka, Bangladesh

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Source of Support: None, Conflict of Interest: None

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Adipose tissue derived a novel adipokine; omentin -1, w hich has recently been characterized as a potent insulin-sensitizing agent, but its pathophysiologic role in the development of insulin resistance among the impaired glucose tolerance (IGT) su bjects remains largely unknow n. The present study has been undertaken to explore the relationship of serum omentin -1 w ith insulin resistance in new ly diagnosed IGT subjects of Bangladeshi population. Fifty-five subjects w ith IGT and 50 (age, sex and body m ass index (BMI) matched) healthy control subjects w ere recruited in this study. Serum insulin and omentin-1 w ere measured by the ELISA technique. Insulin resistance (IR) w as calculated by homeostasis model assessment (HOMA). HOMA-IR w as significantly higher (p < 0.001) as w ell as log transformed omentin-1 w as significantly low er (p = 0.031) in IGT subjects compared to the control. Pearson's correlation analysis show ed a significant negative correlation of log omentin -1 w ith HOMA-IR (r = -0.290, p = 0.008) in all subjects. Multiple linear regression analysis show ed a significant negative association of HOMA-IR w ith log omentin-1 (β = -0.285, p = 0.017) in IGT subjects after adjusting the effects of potential confounders of glycated hemoglobin (HbA1c) and triglyceride (TG). Binary logistic regression analysis show ed that log omentin-1 [odds ratio (OR) = 0.631, p = 0.038] and HOMA-IR (OR = 1.998, p = 0.029) w ere found to be significant determinants of IGT after adjusting the effect of HbA1c and TG. Serum concentration of omentin-1 is decreased in the state of insulin resistance of IGT subjects and this reduction seemed to be mediated by adiposity and hyperglycemia among these subjects.

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