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Year : 2015  |  Volume : 6  |  Issue : 1  |  Page : 4

Evaluation of protein oxidation and its association with total oxidants and antioxidants among type 2 diabetics in Asians

1 Department of Biochemistry, NRS Medical College, Kolkata, West Bengal; Department of Biochemistry, Calcutta National Medical College. Kolkata, West Bengal, India
2 Department of Biochemistry, Calcutta National Medical College. Kolkata, West Bengal, India

Correspondence Address:
K Kar
Assistant Professor, Department of Biochemistry, Calcutta National Medical College, .32 Gorachand Road, Kolkata 700014, West Bengal, India

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Source of Support: None, Conflict of Interest: None

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Incidence and prevalence of type 2 diabetes and its complications are increasing worldwide but more in Asian countries. Oxidative stress is believed to be a common pathogenic factor for initiation for its grave consequences. Advanced oxidation protein product (AOPP) is a marker of protein damage whereas total oxidant status (TOS) reflects the severity of oxidative stress. Variation in results was found by different authors about association between these markers and antioxidant status in a limited number of studies. This cross sectional study was conducted among 50 patients who were clinically diagnosed type 2 diabetes, aged 47 and sex matched controls were selected for the study according to inclusion and exclusion criteria. We analyzed HbA1C, AOPP, TOS and Trolox Equivalent Antioxidant Capacity (TEAC) in diabetes patients and compared them with controls. (HbA1C was estimated by boronate affinity chromatography and others were estimated spectrophotometrically. Significant increase in mean HbA1C, AOPP (p<0.0001) and increase in mean TOS level (p<0.184) were found in diabetes patients in comparison to controls. We also observed significant decrease in mean TEAC levels (p<0.0001). Regression analysis showed the dependence of TEAC on AOPP (r= -0.99, p<0.0001, y=1.607-0.004x). AOPP accumulation is correlated with increased antioxidant consumption in type 2 diabetes. Estimation of AOPP is very much beneficial for prediction of chronic and grave complications of type 2 diabetes.

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