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Year : 2011  |  Volume : 2  |  Issue : 1  |  Page : 3

Blood Sugar lowering effect of zinc and multi vitamin/ mineral supplementation is dependent on initial fasting blood glucose

1 Coronary Care Unit, Teaching Hospital, Karapitiya, Galle. Sri Lanka
2 Nuclear Medicine Unit, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka
3 Department of Community Medicine, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka
4 Department of Medicine, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka

Correspondence Address:
M Hettiarachchi
Senior Lecturer in Nuclear Medicine, Faculty of Medicine, University of Ruhuna, Galle. Sri Lanka

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Source of Support: None, Conflict of Interest: None

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To evaluate the effect of zinc and other multi vitamin mineral supplementation on glycemic control and lipid profile in patients with type 2 diabetes mellitus. Diabetes patients (n=96) were randomly allocated to 3 groups; 29 subjects were supplemented with oral zinc sulfate (22 mg/day) and multivitamin mineral (zinc+MVM) preparation; 31 subjects were supplemented with the same preparation, without zinc (MVM) and 36 were given a matching placebo, for a period of 4 months in a single blinded study. Blood samples were taken at the baseline and after 4 months of supplementation, to assess blood glucose (fasting and post prandial) and glycosylated haemoglobin % (HbA1C%)levels. The Zinc+MVM group had a mean change of fasting blood sugar (FBS) -0.33 (SEM, 0.21) mmol/l and was significant (p =0.05) when compared with the other two groups (mean change in the MVM group +0.19 (0.31) and +0.43 (0.23) mmol/l in the control group respectively). When the baseline FBS was >5.56 (>100mg/dL) mmol/l, supplementation either with Zinc+MVM (p<0.001) or MVM (p=0.02) resulted in a significant favourable effect on blood glucose parameters. The HbA1C% level was lowered significantly irrespective of the baseline HbA1C% concentration, only in Zinc+MVM (p=0.01) supplemented individuals. In the other two groups, the change of HbA1C% level was not significant. Zinc supplementation with other multi vitamins daily to adult diabetes patients who had high baseline FBS levels demonstrated better glycemic control.

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